Derek LeRoith Selected Research

Lipids

1/2022	Distinct Lipidomic Signatures in People Living With HIV: Combined Analysis of ACTG 5260s and MACS/WIHS.
1/2020	Obesity, Type 2 Diabetes, and Cancer Risk.
10/2017	Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice.
10/2016	Metabolic syndrome and pre-diabetes contribute to racial disparities in breast cancer outcomes: hypothesis and proposed pathways.
12/2015	Ovariectomy is associated with metabolic impairments and enhanced mammary tumor growth in MKR mice.
5/2013	Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis.
1/2007	Dyslipidemia and glucose dysregulation in overweight and obese patients.
10/2004	Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.
7/2003	Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.

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Derek LeRoith Research Topics

Disease

58	Neoplasms (Cancer) 01/2023 - 02/2002
41	Type 2 Diabetes Mellitus (MODY) 10/2021 - 10/2002
36	Insulin Resistance 01/2022 - 10/2002
31	Breast Neoplasms (Breast Cancer) 01/2023 - 08/2003
21	Hyperinsulinism (Hyperinsulinemia) 01/2019 - 11/2004
20	Obesity 10/2021 - 12/2006
15	Hyperglycemia 01/2023 - 10/2002
8	Neoplasm Metastasis (Metastasis) 01/2022 - 02/2002
7	Dyslipidemias (Dyslipidemia) 11/2018 - 11/2004
6	Inflammation (Inflammations) 01/2023 - 03/2005
4	Hypoglycemia (Reactive Hypoglycemia) 07/2023 - 06/2003
4	Hypercholesterolemia 01/2023 - 12/2015
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2023 - 11/2007
4	Lung Neoplasms (Lung Cancer) 11/2021 - 02/2002
4	Triple Negative Breast Neoplasms 01/2021 - 10/2014
4	Carcinogenesis 04/2018 - 09/2010
4	Body Weight (Weight, Body) 10/2017 - 02/2011
3	Diabetes Mellitus 01/2023 - 02/2004
3	Sepsis (Septicemia) 01/2023 - 01/2017
2	Cognitive Dysfunction 01/2020 - 10/2015
2	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 07/2015
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 06/2016 - 07/2015
2	Carcinoma (Carcinomatosis) 09/2015 - 05/2013
2	Colorectal Neoplasms (Colorectal Cancer) 02/2015 - 04/2008
2	Fatty Liver 05/2013 - 11/2004
2	Hyperplasia 06/2011 - 06/2003
2	Hypertrophy 10/2010 - 11/2008
2	Prostatic Neoplasms (Prostate Cancer) 03/2010 - 05/2008
2	Osteosarcoma (Osteogenic Sarcoma) 05/2009 - 10/2003
2	Adenocarcinoma 05/2008 - 02/2002
2	Colonic Neoplasms (Colon Cancer) 04/2008 - 02/2002
2	Starvation 12/2004 - 06/2004
1	Chromosome Aberrations (Chromosome Abnormalities) 01/2022
1	HIV Infections (HIV Infection) 01/2022
1	Multiple Organ Failure (MODS) 01/2022

Drug/Important Bio-Agent (IBA)

44	Insulin (Novolin)FDA Link 07/2023 - 10/2002
29	Insulin-Like Growth Factor I (IGF-1)IBA 07/2015 - 02/2002
28	Glucose (Dextrose)FDA LinkGeneric 10/2021 - 06/2003
15	Insulin ReceptorIBA 12/2020 - 09/2005
14	Insulin-Like PeptidesIBA 01/2022 - 06/2003
13	IGF Type 1 Receptor (IGF 1 Receptor)IBA 10/2013 - 06/2003
9	LipidsIBA 01/2022 - 07/2003
8	CytokinesIBA 01/2022 - 11/2007
8	Hormones (Hormone)IBA 01/2022 - 12/2006
8	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 04/2010
7	AdipokinesIBA 01/2020 - 02/2011
6	Blood Glucose (Blood Sugar)IBA 10/2021 - 01/2004
6	Triglycerides (Triacylglycerol)IBA 10/2017 - 10/2003
5	CholesterolIBA 01/2023 - 11/2004
5	Proteins (Proteins, Gene)FDA Link 12/2021 - 10/2003
5	Small Interfering RNA (siRNA)IBA 11/2019 - 06/2004
5	Growth Hormone (Somatotropin)IBA 10/2017 - 10/2003
5	Hypoglycemic Agents (Hypoglycemics)IBA 12/2016 - 09/2005
5	Messenger RNA (mRNA)IBA 09/2015 - 10/2003
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 02/2002
4	Estrogens (Estrogen)FDA Link 12/2020 - 12/2006
4	Nonesterified Fatty Acids (NEFA)IBA 06/2019 - 10/2002
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2016 - 02/2002
4	Transcription Factors (Transcription Factor)IBA 01/2016 - 10/2003
4	Tumor Viral Antigens (Large T Antigen)IBA 01/2016 - 08/2003
4	Insulin-Like Growth Factor II (Somatomedin A)IBA 10/2014 - 06/2003
3	LDL CholesterolIBA 01/2023 - 01/2018
3	Estrogen ReceptorsIBA 09/2022 - 03/2012
3	Somatomedin Receptors (Somatomedin Receptor)IBA 12/2020 - 12/2013
3	ChemokinesIBA 01/2020 - 12/2013
3	LeptinIBA 12/2013 - 09/2005
3	CarbohydratesIBA 01/2012 - 11/2004
3	Insulin-Like Growth Factor Binding Protein 3IBA 10/2003 - 09/2002
2	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2023 - 02/2009
2	LDL Receptors (LDL Receptor)IBA 01/2023 - 01/2021
2	Peptide Hormones (Polypeptide Hormones)IBA 01/2022 - 10/2012
2	Cadherins (E-Cadherin)IBA 01/2022 - 01/2016
2	Estradiol (Delestrogen)FDA LinkGeneric 12/2020 - 12/2015
2	salicylhydroxamic acid (SHAM)IBA 01/2020 - 12/2015
2	Interleukin-6 (Interleukin 6)IBA 11/2018 - 01/2016
2	LigandsIBA 11/2018 - 02/2007
2	Lysine (L-Lysine)FDA Link 04/2018 - 08/2006
2	Arginine (L-Arginine)FDA Link 04/2018 - 08/2006
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2018 - 01/2007
2	Insulin Glargine (Lantus)FDA Link 01/2017 - 01/2016
2	Sirolimus (Rapamycin)FDA Link 12/2016 - 12/2010
2	Advanced Glycation End ProductsIBA 04/2016 - 03/2005
2	VimentinIBA 01/2016 - 06/2013
2	disodium (R,R)- 5- (2- ((2- (3- chlorophenyl)- 2- hydroxyethyl)- amino)propyl)- 1,3- benzodioxole- 2,3- dicarboxylateIBA 01/2016 - 03/2010
2	AdiponectinIBA 12/2013 - 08/2006
2	SteroidsIBA 10/2012 - 12/2006
2	Streptozocin (Streptozotocin)FDA Link 12/2004 - 06/2003
2	PPAR alphaIBA 04/2004 - 07/2003
1	Glucagon-Like Peptide-1 ReceptorIBA 07/2023
1	oxidized low density lipoproteinIBA 01/2023
1	Bromodeoxyuridine (BrdU)IBA 01/2023
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2023
1	tyrosine receptor (receptor, tyrosine)IBA 01/2022
1	Vasopressins (Vasopressin)IBA 01/2022
1	Phosphotransferases (Kinase)IBA 01/2022
1	Oxytocin (Pitocin)FDA LinkGeneric 01/2022

Therapy/Procedure

25	Therapeutics 01/2023 - 03/2004
4	Glycemic Control 10/2015 - 01/2007
3	Drug Therapy (Chemotherapy) 12/2016 - 03/2004
1	Art Therapy 01/2022